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There is a tendency to put the home office in an undesirable location; after all, most of the places in a house are taken. But you are going to be putting in a lot of hours, you have to be able to concentrate and you have to stay healthy. You will need a bit of privacy from the kids; even Teddy Roosevelt had trouble coping, reportedly saying about his oldest daughter: "I can be president of the United States, or I can control Alice. I cannot possibly do both."
So get some privacy, and fresh air, and avoid the basement. Read more at Home Office Tricks: Watch out for Dangers . Also be careful about solvents and chemicals; be sure to use green, voc free cleaners. More at Detox Your Home: In the Office, Part 1. If you must have a laser printer, use it sparingly; they put out particulates and ozone. More at Are Laser Printers As Dangerous as Smoking or as Making Toast?
Read the next page "Green your office equipment."