When you have a blister it can be a pain in the, well, foot, for sure, but there's an easy way to prevent friction blisters without buying special socks or shoes or whatever else you may have tried: A study conducted with groups of cadets at the U.S. Military Academy at West Point, N.Y., found that applying antiperspirant to your feet reduces your odds of developing foot blisters. While as many as 48 percent of the cadets who used a placebo treatment complained of blisters, only 21 percent of those who treated their feet with antiperspirant before hiking suffered any foot blisters [source: Knapik].
Here's why: Friction causes blisters, and when your skin is sweaty or moist, you increase that friction and the odds of developing blisters. Antiperspirant fixes this problem because it's made to reduce sweat -- in this case you're just using it on feet instead of underarms. To prevent a white mess, use a clear stick or a spray.