Muskmelon is a warm-weather plant that will not tolerate even the slightest frost. It also has a long growing season, which means you must select a variety suited to your region's climate. In cool areas, grow muskmelons from transplants; use individual, plantable containers so the root system is not disturbed when you transplant. Set the plant in the garden when the ground is warm: two to three weeks after the danger of frost.
Muskmelon, cantaloupe can be grown from seeds or by transplants.
Muskmelons must have full sun and need a well-drained soil that is high in organic matter. Grow muskmelons in inverted hills spaced 4 to 6 feet apart. If you're planting from seed, plant six to eight seeds per hill and then thin to the strongest two or three seedlings. If you're using transplants, put two or three in each hill. Muskmelons need a lot of water while the vines are growing, but stop watering when the fruit ripens.